Inside A Microscopic Factory: How Bacteria Organize Proteins For Infection

Serine phosphorylation of CesT by the type III secretion system effectors NleH1 and NleH2 regulates antagonization of CsrA in enteropathogenic Escherichia coli Esther Tang 1, Angeline C Beltran 1, Senthuran Mahendradeva 1, Abiali A Badani 1, Dustin J Little Like pirates boarding a ship they’re about to raid, food-poisoning bacteria inject proteins into the cells lining our small intestine to hijack them. This createsContinue reading "Inside A Microscopic Factory: How Bacteria Organize Proteins For Infection"

How Does a Cancer Cell Hit The Big Red Button?

The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptoticsignaling in carcinomasPauline G. Knox,1,2 Clare C. Davies, 3Marina Ioannou,2 and Aristides G. Eliopoulos1,2 Image generated by author Normally, when a cell senses it’s becoming cancerous, it can press the self-destruct button to protect the body. However, mutations in this mechanism can keep aContinue reading "How Does a Cancer Cell Hit The Big Red Button?"

Neurons to Network: Scientists Upload a Fly’s Brain

A Drosophila computational brain model reveals sensorimotor processing Philip K. Shiu, Gabriella R. Sterne, Nico Spiller, Romain Franconville, Andrea Sandoval, Joie Zhou, Neha Simha, Chan Hyuk Kang, Seongbong Yu, Jinseop S. Kim, Sven Dorkenwald, Arie Matsliah, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Amy Sterling, Marta Costa, Katharina Eichler, Alexander Shakeel Bates, Nils Eckstein, JanContinue reading "Neurons to Network: Scientists Upload a Fly’s Brain"

Scientists Arm Immune Cells To Combat Aggressive Brain Tumors: Early Trial Results

Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial Christine E. Brown, Jonathan C. Hibbard, Darya Alizadeh, M. Suzette Blanchard, Heini M. Natri, Dongrui Wang, Julie R. Ostberg, Brenda Aguilar, Jamie R. Wagner, Jinny A. Paul, Renate Starr, Robyn A. Wong, Wuyang Chen, Noah Shulkin, Maryam Aftabizadeh, Aleksandr Filippov, AmmarContinue reading "Scientists Arm Immune Cells To Combat Aggressive Brain Tumors: Early Trial Results"