Bringing Silicon to Drugs: Modular Construction of Sila-Pharmacophores for the Development of Target Protein Degraders Zhigang Wu, Xujiang Zhu, Yueqiu Li, Xia Wang, Meizhen Huang, Zhenyuan Dong, Jiangnan Zheng, Ruijun Tian, Chuan He, and Jie Wang Most cancer drugs work by blocking the activity of harmful proteins, but the proteins themselves remain inside the cell. ThisContinueContinue reading “Silicon, Not Carbon: The Surprising Element That’s Revolutionizing Cancer Drug Design”
Author Archives: Jayde Casimir-Powell
New Drug May Nearly Double Survival for Some Patients with Pancreatic Cancer
Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer Eileen M. O’Reilly, M.D., Zev A. Wainberg, M.D., Andrew E. Hendifar, M.D., Mitesh J. Borad, M.D., Filippo Pietrantonio, M.D., Shubham Pant, M.D., Pascal Hammel, M.D., Chiara Cremolini, M.D., Ph.D., Gulam A. Manji, M.D., Ph.D., Paul E. Oberstein, M.D., Ignacio Garrido-Laguna, M.D., Ph.D., Christoph Springfeld, M.D., Ph.D.,ContinueContinue reading “New Drug May Nearly Double Survival for Some Patients with Pancreatic Cancer “
This Brain-Computer Connection Can Translate Imagined Handwriting Into Text
Cortical representation of multidimensional handwriting movement and implications for neuroprostheses Zebin Wang 1,2,3, Guangxiang Xu 1,2,3, Bowen Yu 1,2,3, Kedi Xu 3, Junming Zhu 4, Gang Pan 1,5, Jianmin Zhang 4, Yueming Wang 2,5,✉, Yaoyao Hao 1,2,5,✉ People living with paralysis often lose one of the most fundamental aspects of human experience: the ability to communicate easily with others. Researchers are now developing brain-computer interfaces (BCIs) that could help restore communication byContinueContinue reading “This Brain-Computer Connection Can Translate Imagined Handwriting Into Text”
A New Category of Breast Cancer Is Changing Treatment Options
Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast CancerShanu Modi, M.D., William Jacot, M.D., Ph.D., Toshinari Yamashita, M.D., Ph.D., Joohyuk Sohn, M.D. https://orcid.org/0000-0002-2303-2764, Maria Vidal, M.D., Ph.D., Eriko Tokunaga, M.D., Ph.D., Junji Tsurutani, M.D., Ph.D., +31 , for the DESTINY-Breast04 Trial Investigators* For many people, a breast cancer diagnosis is quickly followed by a secondContinueContinue reading “A New Category of Breast Cancer Is Changing Treatment Options”
Replacing Lost Neurons in Parkinson’s Disease: Early Clinical Results of Bemdaneprocel
Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease V. Tabar, H. Sarva, A. M. Lozano, A. Fasano, S. K. Kalia, K. K. H. Yu, C. Brennan, Y. Ma, S. Peng, D. Eidelberg, M. Tomishima, S. Irion, W. Stemple, N. Abid, A. Lampron, L. Studer & C. Henchcliffe For millions of people living withContinueContinue reading “Replacing Lost Neurons in Parkinson’s Disease: Early Clinical Results of Bemdaneprocel”
What If Aging and Vision Loss Could Be Reversed? Rewinding the Cellular Clock
Reprogramming to recover youthful epigenetic information and restore vision Yuancheng Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, Qiurui Zeng, Doudou Yu, Michael S. Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma M. Hoffmann, Margarete M. Karg, Michael B. Schultz, Alice E. Kane, Noah Davidsohn, Ekaterina Korobkina, Karolina Chwalek, Luis A.ContinueContinue reading “What If Aging and Vision Loss Could Be Reversed? Rewinding the Cellular Clock”
AI Is A Tool, Not A Craftsman
Letter From the Editor Is it real or is it cake? We live in a time where machines can imitate human intelligence with increasing precision, making it reasonable to mistake imitation for reality. This rapid advancement has led many to wonder whether human workers are on the verge of being replaced—whether writers, artists, and evenContinueContinue reading “AI Is A Tool, Not A Craftsman”
Science Isn’t Failing Us, We are Failing Science.
Letter From The Editor Centuries ago, early thinkers made discoveries that reshaped human understanding. Hippocrates laid the foundations of medicine, Pythagoras transformed our understanding of geometry, and Democritus proposed that matter itself is composed of atoms. What made these contributions powerful was not just their impact, but their origin: a deep curiosity about how theContinueContinue reading “Science Isn’t Failing Us, We are Failing Science.”
Planning to start tanning? Read this first.
Sunscreens and Photoprotection Sarah Gabros; Preeti Patel; Patrick M. Zito In this digital age with all the sunscreen marketing, it’s fairly easy to be influenced on which sunscreen you should buy. However, in this review, they show indeed that not all sunscreens are made equal. Everyone knows that going without sunscreen might mean sunburns, andContinueContinue reading “Planning to start tanning? Read this first.”
Scientists Create Algorithm that Learns To Identify Patterns in Cells
Cell-DINO: Self-supervised image-based embeddings for cell fluorescent microscopy Théo Moutakanni,Camille Couprie,Seungeun Yi,Michael Doron,Zitong S. Chen,Nikita Moshkov,Elouan Gardes,Mathilde Caron,Hugo Touvron,Armand Joulin,Piotr Bojanowski,Wolfgang M. Pernice,Juan C. Caicedo Microscopy is a powerful way to study what’s happening inside cells, but researchers often collect hundreds or thousands of images. This large volume of data makes it incredibly difficult toContinueContinue reading “Scientists Create Algorithm that Learns To Identify Patterns in Cells”